Detalhe da pesquisa
1.
HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis.
Cell
; 166(5): 1257-1268.e12, 2016 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27565348
2.
Second-Line Switch to Dolutegravir for Treatment of HIV Infection.
N Engl J Med
; 388(25): 2349-2359, 2023 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37342923
3.
Structure of a HIV-1 IN-Allosteric inhibitor complex at 2.93 Å resolution: Routes to inhibitor optimization.
PLoS Pathog
; 19(3): e1011097, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36867659
4.
Pharmacogenetics of weight gain following switch from efavirenz- to integrase inhibitor-containing regimens.
Pharmacogenet Genomics
; 34(2): 25-32, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37910437
5.
Cabotegravir for HIV Prevention in Cisgender Men and Transgender Women.
N Engl J Med
; 385(7): 595-608, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34379922
6.
Dolutegravir as First- or Second-Line Treatment for HIV-1 Infection in Children.
N Engl J Med
; 385(27): 2531-2543, 2021 12 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34965338
7.
Energy balance and body composition after switch between integrase strand transfer inhibitors and doravirine among people with HIV.
J Antimicrob Chemother
; 79(1): 179-185, 2024 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38000089
8.
HIV-1 3'-Polypurine Tract Mutations Confer Dolutegravir Resistance by Switching to an Integration-Independent Replication Mechanism via 1-LTR Circles.
J Virol
; 97(5): e0036123, 2023 05 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37125907
9.
Clinical significance and management of low-level HIV viremia in the era of integrase strand transfer inhibitors.
HIV Med
; 25(3): 361-369, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-37990782
10.
Efficacy, safety, and tolerability of dolutegravir-based ART regimen in Durban, South Africa: a cohort study.
BMC Infect Dis
; 24(1): 343, 2024 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38515041
11.
The effect of a treatment switch to integrase Strand transfer inhibitor-based regimens on weight gain and other metabolic syndrome-related conditions.
BMC Infect Dis
; 24(1): 221, 2024 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38373940
12.
Characterization of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification.
Nucleic Acids Res
; 50(3): 1484-1500, 2022 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35037045
13.
Synergistic antiviral activity against drug-resistant HIV-1 by naturally occurring dipeptide and A single-stranded oligonucleotide.
Drug Resist Updat
; 68: 100955, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36878096
14.
Effect of the L74I Polymorphism on Fitness of Cabotegravir-Resistant Variants of Human Immunodeficiency Virus 1 Subtype A6.
J Infect Dis
; 228(10): 1352-1356, 2023 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37497681
15.
Changes in Body Mass Index with Longer-term Integrase Inhibitor Use: A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE).
Clin Infect Dis
; 76(11): 2010-2013, 2023 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36825498
16.
Transmitted Drug Resistance to Integrase-Based First-Line Human Immunodeficiency Virus Antiretroviral Regimens in Mediterranean Europe.
Clin Infect Dis
; 76(9): 1628-1635, 2023 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36571282
17.
Plasma Human Immunodeficiency Virus 1 RNA and CD4+ T-Cell Counts Are Determinants of Virological Nonsuppression Outcomes With Initial Integrase Inhibitor-Based Regimens: A Prospective RESPOND Cohort Study.
Clin Infect Dis
; 77(4): 593-605, 2023 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37052343
18.
Pharmacokinetic Data of Dolutegravir in Second-line Treatment of Children With Human Immunodeficiency Virus: Results From the CHAPAS4 Trial.
Clin Infect Dis
; 77(9): 1312-1317, 2023 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37280040
19.
Impact of Integrase Inhibitors on Cardiovascular Disease Events in People With Human Immunodeficiency Virus Starting Antiretroviral Therapy.
Clin Infect Dis
; 77(5): 729-737, 2023 09 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37157869
20.
Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase.
Antimicrob Agents Chemother
; 67(7): e0046223, 2023 07 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37310224